Looking for the ultimate comfort food combination? This Mac and Cheese Meatloaf Casserole brings together two classic favorites—rich, cheesy macaroni and savory meatloaf—in one decadent dish. Perfect for weeknight dinners, family gatherings, or even a fun twist on traditional comfort food, this casserole is hearty, flavorful, and oh-so-satisfying. Read on to learn how to create this irresistible recipe that’s sure to be a hit with the entire family!
What Is a Mac and Cheese Meatloaf Casserole?
Mac and Cheese Meatloaf Casserole combines layers of cheesy, creamy macaroni and cheese with a flavorful meatloaf base. It’s a delicious fusion of two comforting, hearty meals baked together for a cheesy, meaty dish that’s filling and full of flavor. This casserole is perfect for a crowd and can be made ahead of time, making it a great choice for busy families or casual get-togethers. The combination of tender ground beef, savory seasonings, and rich mac and cheese makes this dish an all-in-one comfort food delight.
Ingredients List for Mac and Cheese Meatloaf Casserole
To make this mouthwatering Mac and Cheese Meatloaf Casserole, you’ll need the following ingredients:
For the Meatloaf Layer:
- 1 lb ground beef (or ground turkey, chicken, or pork)
- 1 small onion, finely chopped
- 1 clove garlic, minced
- ½ cup breadcrumbs (or crushed crackers)
- 1 egg
- ¼ cup ketchup
- 2 tablespoons mustard (yellow or Dijon)
- 1 tablespoon Worcestershire sauce
- ½ teaspoon garlic powder
- ½ teaspoon onion powder
- Salt and pepper to taste
For the Mac and Cheese Layer:
- 2 cups elbow macaroni (or other pasta)
- 2 cups shredded cheddar cheese (or a combination of cheeses like Monterey Jack, mozzarella, etc.)
- 2 tablespoons butter
- 2 tablespoons all-purpose flour
- 2 cups milk (whole or 2%)
- ½ teaspoon garlic powder
- ½ teaspoon mustard powder (optional, for flavor)
- Salt and pepper to taste
- ¼ cup grated Parmesan cheese (optional, for added cheesiness)
- ½ cup breadcrumbs (optional, for topping)
- 1 tablespoon melted butter (for mixing with breadcrumbs)
Substitutions and Variations
This recipe is very flexible, allowing for plenty of substitutions and variations to suit your taste or dietary needs:
- Ground Beef: Substitute with ground turkey, chicken, or pork for a lighter version. You can also use a plant-based ground meat alternative for a vegetarian option.
- Cheese: Use your favorite cheese combinations for the mac and cheese. Cheddar is a classic, but try adding mozzarella, Monterey Jack, Gruyère, or even a bit of blue cheese for extra flavor.
- Breadcrumbs: Use panko breadcrumbs for extra crunch, or swap with crushed crackers, cornflakes, or even a gluten-free option if needed.
- Toppings: Add some crispy bacon bits, a sprinkle of chives, or even a drizzle of barbecue sauce over the casserole for added flavor and texture.
- Vegetables: Mix in veggies like spinach, peas, or chopped broccoli to boost the nutrition.
Step-by-Step Cooking Instructions

Here’s how to make this delicious Mac and Cheese Meatloaf Casserole step by step:
For the Meatloaf Layer:
- Preheat your oven: Preheat the oven to 350°F (175°C).
- Prepare the meatloaf mixture: In a large bowl, combine the ground beef, chopped onion, minced garlic, breadcrumbs, egg, ketchup, mustard, Worcestershire sauce, garlic powder, onion powder, salt, and pepper. Mix everything together until well combined.
- Press the meatloaf into a baking dish: Grease a 9x13-inch baking dish and press the meatloaf mixture evenly into the bottom of the dish, forming a flat layer. Set aside while you prepare the mac and cheese.
For the Mac and Cheese Layer:
- Cook the pasta: Bring a large pot of salted water to a boil and cook the macaroni until al dente, according to the package instructions. Drain and set aside.
- Make the cheese sauce: In a medium saucepan, melt the butter over medium heat. Whisk in the flour and cook for 1-2 minutes to form a roux, stirring constantly. Gradually whisk in the milk and continue cooking until the mixture thickens, about 3-5 minutes.
- Add the cheese and seasonings: Once the sauce has thickened, remove it from heat and stir in the shredded cheddar cheese, Parmesan (if using), garlic powder, mustard powder (if using), salt, and pepper. Stir until the cheese is fully melted and the sauce is smooth.
- Combine with the pasta: Pour the cheese sauce over the cooked macaroni and stir until the pasta is well coated.
Assembly and Baking:
- Layer the casserole: Spoon the macaroni and cheese evenly over the top of the meatloaf layer in the baking dish.
- Add the breadcrumb topping: If you’re adding a crunchy topping, mix the breadcrumbs with melted butter and sprinkle them evenly over the mac and cheese layer.
- Bake: Place the casserole in the preheated oven and bake for 25-30 minutes, or until the top is golden brown and the meatloaf is cooked through.
- Cool slightly and serve: Let the casserole cool for a few minutes before cutting into it. Serve warm and enjoy!
How to Cook Mac and Cheese Meatloaf Casserole: A Step-by-Step Guide
Here’s a quick recap of the process to make this Mac and Cheese Meatloaf Casserole:
- Prepare the meatloaf base by mixing ground beef, seasonings, and breadcrumbs, and press it into a baking dish.
- Make the mac and cheese with a creamy, homemade cheese sauce and cooked pasta.
- Layer the mac and cheese over the meatloaf, and optionally top with buttered breadcrumbs for a crunchy finish.
- Bake until golden and cooked through, then let it cool slightly before serving.
Common Mistakes to Avoid
Even with an easy casserole like this, there are a few common mistakes to avoid:
- Not seasoning the meatloaf enough: Be sure to season the meatloaf mixture generously with salt, pepper, and other seasonings to ensure it’s flavorful.
- Overcooking the pasta: Cook the macaroni just until al dente since it will continue to cook in the oven. Overcooked pasta can become mushy in the casserole.
- Too much liquid in the cheese sauce: Be careful when making the cheese sauce. If it’s too thin, it can make the mac and cheese watery. Let the sauce thicken before adding the cheese.
- Skipping the resting time: Let the casserole rest for a few minutes before slicing. This will help it hold its shape better when serving.
Serving and Presentation Tips
This Mac and Cheese Meatloaf Casserole is a meal in itself, but here are a few ideas to make your presentation more special:
- Garnish with fresh herbs: Add a sprinkle of fresh parsley or chives over the top for a pop of color and flavor.
- Serve with a side salad: A light green salad with a tangy vinaigrette can balance out the richness of the casserole.
- Add extra toppings: Drizzle a bit of barbecue sauce or ketchup over each serving, or sprinkle crispy bacon bits on top for added texture and flavor.
How to Serve Mac and Cheese Meatloaf Casserole
This casserole is a hearty dish that can be served as a stand-alone meal, but you can pair it with a few sides for a complete dinner:
- Salads: A crisp green salad, coleslaw, or roasted vegetable salad would pair well with the rich casserole.
- Bread: Serve with warm garlic bread, dinner rolls, or biscuits to soak up any extra cheesy sauce.
- Vegetables: Steamed or roasted vegetables, such as green beans, Brussels sprouts, or broccoli, make great side dishes.
Presentation Ideas for Mac and Cheese Meatloaf Casserole
Make your Mac and Cheese Meatloaf Casserole look even more inviting with these presentation ideas:
- Use a beautiful baking dish: A colorful ceramic or glass baking dish can make the meal look more festive right out of the oven.
- Garnish with herbs or cheese: Add a sprinkle of fresh parsley or extra cheese on top before serving for a professional look.
- Serve in individual ramekins: For a more elegant presentation, bake the casserole in individual ramekins for personalized portions.
Mac and Cheese Meatloaf Casserole Recipe Tips
To ensure your Mac and Cheese Meatloaf Casserole turns out perfectly every time, here are some helpful tips:
- Make it ahead: You can assemble the casserole ahead of time and refrigerate it for up to 24 hours before baking. Just pop it in the oven when you’re ready.
- Freeze leftovers: This casserole freezes well. Let it cool completely, then wrap it tightly and store it in the freezer for up to 3 months. Thaw overnight in the fridge before reheating.
- **Adjust the cheese sauce
:** If you prefer a creamier mac and cheese, feel free to add more cheese to the sauce or a splash of heavy cream for extra richness.
Frequently Asked Questions (FAQs)
Q: Can I make this casserole ahead of time?
A: Yes! You can assemble the casserole and store it in the refrigerator for up to 24 hours before baking. This makes it a great option for meal prep or busy weeknights.
Q: Can I freeze Mac and Cheese Meatloaf Casserole?
A: Absolutely! This casserole freezes well. Let it cool completely, then wrap it tightly and freeze for up to 3 months. Thaw overnight in the fridge and reheat when ready.
Q: Can I use store-bought mac and cheese?
A: Yes, if you’re short on time, you can use boxed mac and cheese instead of making it from scratch. Just prepare the mac and cheese according to the package instructions and proceed with the recipe.
Q: How can I make this dish healthier?
A: To lighten it up, use ground turkey or chicken for the meatloaf, substitute whole wheat pasta or veggie pasta, and opt for reduced-fat cheese and milk in the mac and cheese.
Conclusion
This Mac and Cheese Meatloaf Casserole is the ultimate comfort food mash-up, combining the savory goodness of meatloaf with creamy, cheesy mac and cheese. It’s a fun, satisfying dish that’s perfect for feeding a hungry family or impressing guests at a casual gathering. Plus, it’s easy to customize with your favorite cheeses, seasonings, and toppings. Give this recipe a try, and enjoy the rich, comforting flavors of two classic dishes baked together in one delicious casserole!
PrintMac And Cheese Meatloaf Casserole Recipe
This Mac and Cheese Meatloaf Casserole brings together two comfort food favorites in one dish. Juicy, flavorful meatloaf is topped with creamy, cheesy macaroni and baked to perfection for a hearty, satisfying meal. Perfect for busy weeknights, this dish is a family favorite that’s sure to please all ages!
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: 6 servings 1x
- Category: Dinner
- Method: Baking
- Cuisine: American
- Diet: Gluten Free
Ingredients
- 1 lb ground beef
- ½ cup breadcrumbs
- 1 egg
- ¼ cup milk
- 1 small onion (diced)
- ¼ cup ketchup (plus more for topping)
- 1 tsp garlic powder
- 1 tsp salt
- ½ tsp pepper
- 2 cups cooked macaroni
- 2 cups shredded cheddar cheese
- ½ cup milk (for mac and cheese)
- 2 tbsp butter
- 2 tbsp flour
Instructions
- Preheat oven to 350°F (175°C).
- In a bowl, combine ground beef, breadcrumbs, egg, milk, onion, ketchup, garlic powder, salt, and pepper. Mix until combined.
- Press the meatloaf mixture into the bottom of a greased 9x9 inch casserole dish.
- Bake for 25 minutes until the meatloaf is partially cooked.
- In a saucepan, melt butter and whisk in flour. Gradually add milk, stirring until thickened. Stir in cheddar cheese until melted and smooth.
- Toss the cooked macaroni with the cheese sauce, then layer it on top of the partially cooked meatloaf.
- Return to the oven and bake for an additional 20 minutes, until the cheese is bubbly and golden.
- Let cool for 5 minutes before serving.
Notes
- For extra flavor, add bacon bits or chopped herbs to the mac and cheese.
- You can use a combination of ground beef and ground pork for a richer meatloaf.
Nutrition
- Serving Size: 1 cup
- Calories: 520
- Sugar: 4g
- Sodium: 780mg
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