There's nothing quite like the comforting taste of Swiss Chicken Casserole straight from the oven. The creamy sauce, tender chicken, and gooey Swiss cheese combine to create a meal that feels like a warm hug on a chilly evening.
I first discovered this recipe when looking for a way to use up some leftover Swiss cheese. What started as an experiment quickly became a family favorite, appearing on our dinner table whenever we need something quick, easy, and absolutely delicious.
Why You'll Love This Swiss Chicken Casserole
Get ready to fall in love with your new go-to comfort food. This Swiss Chicken Casserole is more than just tasty—it’s a lifesaver on busy weeknights.
First off, it’s incredibly simple to make. With just a handful of ingredients and minimal prep, you can have this casserole in the oven in under 10 minutes. It’s perfect for those evenings when you need a satisfying meal without the fuss.
It’s also a great way to use up pantry staples. If you have some chicken breasts, a can of cream of chicken soup, and a few slices of Swiss cheese, you're already halfway there! Plus, it’s easy to customize with whatever you have on hand.
Another reason to love this dish? It’s perfect for meal prep. Make a big batch, and you’ll have delicious leftovers that reheat beautifully, making lunch the next day just as exciting as dinner.
Lastly, the flavor is absolutely unbeatable. The tangy Swiss cheese melts into the creamy sauce, while the buttery stuffing topping adds the perfect crispy contrast. Every bite is a little piece of comfort.
Ingredients Notes

This Swiss Chicken Casserole comes together with just a few simple ingredients, but each one plays an important role in creating that rich, comforting flavor.
Chicken Breasts – Boneless, skinless chicken breasts are ideal for this recipe. They cook up tender and juicy in the creamy sauce. If you prefer, you can also use boneless chicken thighs for extra moisture.
Swiss Cheese – The star of the show! Swiss cheese melts beautifully, adding a slightly nutty, tangy flavor to balance the richness of the casserole. If you’re not a fan of Swiss, provolone or mozzarella work well too.
Cream of Chicken Soup – This helps create the creamy, luscious sauce that ties everything together. You can use homemade cream of chicken soup if you prefer, or swap it out for cream of mushroom for a slightly different twist.
Sour Cream – This adds a little extra tang and creaminess to the sauce. Greek yogurt can be used as a lighter alternative while still maintaining a rich texture.
Stuffing Mix – The crispy, buttery stuffing topping is what takes this casserole to the next level. I love using herbed stuffing mix, but plain works just as well. If you don’t have stuffing mix, you can substitute with crushed crackers mixed with melted butter.
Special Equipment – You’ll need a 9x13-inch baking dish to ensure even cooking and a crispy topping. If you’re making a smaller batch, an 8x8-inch dish works too!
How To Make This Swiss Chicken Casserole

Making Swiss Chicken Casserole couldn’t be easier. Just a few steps and you’re on your way to a warm, cheesy, satisfying meal.
Start by preheating your oven to 350°F (175°C). While the oven warms up, lightly grease a 9x13-inch baking dish to prevent sticking.
Next, arrange the chicken breasts in a single layer at the bottom of the dish. If they’re particularly thick, consider slicing them in half or pounding them slightly to ensure even cooking.
Layer the Swiss cheese slices over the chicken, covering each piece completely. Don’t be afraid to overlap them slightly—more cheese is always a good idea!
In a separate bowl, mix the cream of chicken soup and sour cream until smooth. This creamy mixture gets spread evenly over the cheese, ensuring that every bite is full of flavor.
Now for the best part—the crispy stuffing topping. Sprinkle the dry stuffing mix evenly over the top of the casserole. Then, drizzle melted butter over the stuffing to help it brown beautifully in the oven.
Bake uncovered for 45-50 minutes, or until the chicken is cooked through and the stuffing is golden brown. The internal temperature of the chicken should reach 165°F (74°C) for safe eating. Let it rest for a few minutes before serving to allow the flavors to meld together.
Storage Options
This Swiss Chicken Casserole stores wonderfully, making it a great choice for leftovers or meal prep.
If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. The flavors continue to develop, making it just as delicious the next day.
For longer storage, freeze individual portions in freezer-safe containers. It will keep well for up to 3 months. When you're ready to enjoy it, thaw overnight in the refrigerator before reheating.
To reheat, place a portion in the microwave for 1-2 minutes, or bake in a 350°F oven for about 15 minutes until heated through. Add a splash of chicken broth or milk if the casserole seems dry after reheating.
Variations and Substitutions
One of the best things about Swiss Chicken Casserole is how easy it is to adapt to your tastes or dietary needs. Here are a few delicious variations:
Different Cheeses – If you’re not a fan of Swiss, try provolone, mozzarella, or cheddar. Each brings a unique flavor but still melts beautifully.
Low-Carb Version – Skip the stuffing topping and sprinkle crushed pork rinds or almond flour mixed with Parmesan cheese for a keto-friendly version.
Add Veggies – For a one-dish meal, mix in sautéed mushrooms, broccoli, or spinach before baking. This adds extra nutrients and flavor.
Use Rotisserie Chicken – If you’re short on time, shredded rotisserie chicken is a great shortcut. Simply mix it with the soup and cheese, then bake until bubbly.
Gluten-Free Option – Use a gluten-free stuffing mix or crushed gluten-free crackers to make this dish gluten-friendly without sacrificing texture.
No matter how you make it, this Swiss Chicken Casserole is bound to become a regular in your dinner rotation. Give it a try tonight—you won’t regret it!
PrintSwiss Chicken Casserole Recipe
This Swiss Chicken Casserole recipe features juicy chicken breasts topped with creamy Swiss cheese, a rich sauce, and a buttery stuffing crust. Perfect for a comforting family dinner, this easy baked dish is full of flavor and requires minimal prep time.
- Prep Time: 10 minutes
- Cook Time: 45 minutes
- Total Time: 55 minutes
- Yield: 4 servings 1x
- Category: Dinner
- Method: baking
- Cuisine: American
- Diet: Gluten Free
Ingredients
- 4 boneless, skinless chicken breasts
- 6 slices Swiss cheese
- 1 can (10.5 oz) condensed cream of chicken soup
- ½ cup milk
- 1 cup sour cream
- 1 package (6 oz) seasoned stuffing mix
- ¼ cup butter, melted
- ½ teaspoon garlic powder
- ½ teaspoon onion powder
- Salt and pepper to taste
Instructions
- Preheat oven to 350°F (175°C). Grease a 9x13-inch baking dish.
- Place chicken breasts in the dish and season with salt, pepper, garlic powder, and onion powder.
- Lay Swiss cheese slices evenly over the chicken.
- In a bowl, mix cream of chicken soup, milk, and sour cream until smooth. Pour over the chicken and cheese.
- In a separate bowl, combine stuffing mix with melted butter. Sprinkle over the casserole.
- Bake for 40–45 minutes, or until the chicken is cooked through and the topping is golden brown.
- Let sit for 5 minutes before serving. Enjoy!
Notes
- Use rotisserie chicken for a quicker version.
- Substitute Swiss cheese with provolone or mozzarella for a different flavor.
- Add sautéed mushrooms or spinach for extra texture and nutrition.
Nutrition
- Serving Size: 1 piece
- Calories: 450
- Sugar: 3g
- Sodium: 920mg
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